van der Weele G M, Olde Rikkert M G M, Eizenga W H, Assendelft W J J
Nederlands Huisartsen Genootschap, afd. Richtlijnontwikkeling en Wetenschapsbeleid, Postbus 3231, 3502 GE Utrecht.
Ned Tijdschr Geneeskd. 2003 May 17;147(20):965-9.
The Dutch College of General Practitioners' practice guideline 'Delirium in elderly people' contains a number of key messages. These are: Consider the diagnosis of delirium in the case of changes in consciousness and attention, incoherent thinking or disorientation, if this picture developed over a short period of time (hours to days) and if the symptoms vary over the 24-hour period. Delirium is provoked by one or more somatic disorders; investigation and treatment of these disorders is an essential part of managing delirium. It is often difficult to distinguish delirium from dementia and depression. Although delirium is generally reversible, the prognosis in the elderly is relatively poor. If delirium is accompanied by fear or agitation, haloperidol is the drug of first choice, but in delirium induced by alcohol withdrawal or benzodiazepine withdrawal, a short-acting benzodiazepine such as lorazepam or oxazepam is indicated. Part of the treatment, but also prevention of delirium is focused on inducing factors that can provoke a delirium, such as medication with an anticholinergic effect, polypharmacy, inadequate nutrition, dehydration, sleep deprivation, immobility and sensory handicaps.
荷兰全科医生学院的实践指南《老年人谵妄》包含若干关键信息。这些信息如下:如果意识和注意力发生变化、思维不连贯或定向障碍,且这种情况在短时间内(数小时至数天)出现,并且症状在24小时内有所变化,应考虑谵妄的诊断。谵妄由一种或多种躯体疾病引发;对这些疾病的调查和治疗是管理谵妄的重要组成部分。通常很难将谵妄与痴呆和抑郁症区分开来。虽然谵妄一般是可逆的,但老年人的预后相对较差。如果谵妄伴有恐惧或躁动,氟哌啶醇是首选药物,但在酒精戒断或苯二氮䓬类药物戒断所致的谵妄中,应使用短效苯二氮䓬类药物,如劳拉西泮或奥沙西泮。谵妄治疗及预防的一部分工作重点在于诱发谵妄的因素,如具有抗胆碱能作用的药物、多种药物联用、营养不足、脱水、睡眠剥夺、活动减少和感觉障碍。