Carlsson Malin, Hagberg Gudrun, Olsson Ingrid
Department of Paediatrics, Queen Silvia Children's Hospital, Göteborg, Sweden.
Dev Med Child Neurol. 2003 Jun;45(6):371-6. doi: 10.1017/s0012162203000719.
The aims of this retrospective and population-based study were to describe the frequency and characteristics of epilepsy in 146 children (82 males and 64 females) with cerebral palsy (CP) born from 1987 to 1994 in the Göteborg area of Sweden. The frequency of epilepsy was found to be 38% (55 children). All children with tetraplegic CP and about one-third of the children with other CP types developed epilepsy. Age at onset of epilepsy varied with type of CP: children with tetraplegic CP tended to have an earlier onset of epilepsy than children with other CP types. Partial seizures were the most common seizure type; all children with hemiplegic CP had partial seizures. Children with cognitive impairment had a higher frequency of epilepsy than those without cognitive impairment. CP aetiology may predict the development and outcome of epilepsy, as children with CP caused by CNS malformation, CNS infection, and grey matter damage all showed a higher frequency of epilepsy than children with CP of other aetiology, and also had less chance of becoming seizure-free.
这项基于人群的回顾性研究旨在描述1987年至1994年在瑞典哥德堡地区出生的146例脑瘫（CP）儿童（82名男性和64名女性）中癫痫的发生率和特征。癫痫的发生率为38%（55名儿童）。所有四肢瘫型脑瘫儿童以及约三分之一的其他类型脑瘫儿童都患有癫痫。癫痫发作的年龄因脑瘫类型而异：四肢瘫型脑瘫儿童的癫痫发作往往比其他类型脑瘫儿童更早。部分性发作是最常见的发作类型；所有偏瘫型脑瘫儿童都有部分性发作。有认知障碍的儿童癫痫发生率高于无认知障碍的儿童。脑瘫病因可能预示癫痫的发展和转归，因为由中枢神经系统畸形、中枢神经系统感染和灰质损伤导致的脑瘫儿童癫痫发生率均高于其他病因导致的脑瘫儿童，且无癫痫发作的可能性也较小。
