HLA - A3和HLA - B14抗原与特发性血色素沉着症的关联。
Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis.
作者信息
Simon M, Bourel M, Fauchet R, Genetet B
出版信息
Gut. 1976 May;17(5):332-4. doi: 10.1136/gut.17.5.332.
Abstract
The frequency of HLA-A3 and HLA-B14 antigens was significantly higher in a series of 51 patients with idiopathic haemochromatosis than in a control group, being respectively 78-4 versus 27-0% and 25-5 versus 3-4%. This finding strongly supports the suggestion that idiopathic haemochromatosis is a genetic disease and suggests that the gene(s) responsible for the disease may be linked to the histocompatibility genes.
摘要
在一组51例特发性血色素沉着症患者中，HLA - A3和HLA - B14抗原的频率显著高于对照组，分别为78.4%对27.0%以及25.5%对3.4%。这一发现有力地支持了特发性血色素沉着症是一种遗传性疾病的观点，并表明导致该疾病的基因可能与组织相容性基因相关。
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本文引用的文献
1
Idiopathic haemochromatosis: an autosomal recessive disease.特发性血色素沉着症：一种常染色体隐性疾病。
Clin Genet. 1974;5(3):234-41. doi: 10.1111/j.1399-0004.1974.tb01688.x.
2
High association of an HL-A antigen, W27, with ankylosing spondylitis.HL - A抗原W27与强直性脊柱炎高度相关。
N Engl J Med. 1973 Apr 5;288(14):704-6. doi: 10.1056/NEJM197304052881403.
3
The association of the HL-A antigens with diseases.HL-A抗原与疾病的关联。
Clin Immunol Immunopathol. 1974 Sep;3(1):127-49. doi: 10.1016/0090-1229(74)90029-4.
4
Ankylosing spondylitis and HL-A 27.强直性脊柱炎与人类白细胞抗原27
Lancet. 1973 Apr 28;1(7809):904-7. doi: 10.1016/s0140-6736(73)91360-3.
5
Data on the HL-A linkage group.关于组织相容性白细胞抗原连锁群的数据。
Ann Hum Genet. 1975 May;38(4):383-90. doi: 10.1111/j.1469-1809.1975.tb00628.x.
6
[Letter: Idiopathic hemochromatosis associated with HL-A 3 tissular antigen].
Nouv Presse Med. 1975 May 10;4(19):1432.
7
HL-A and disease associations--a survey.人类白细胞抗原与疾病的关联——一项调查。
Transplant Rev. 1975;22:3-43. doi: 10.1111/j.1600-065x.1975.tb01550.x.
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