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HLA determinants in idiopathic hemochromatosis.

作者信息

Fauchet R, Genetet N, Genetet B, Simon M, Bourel M

出版信息

Tissue Antigens. 1979 Jul;14(1):10-4. doi: 10.1111/j.1399-0039.1979.tb00815.x.

DOI:10.1111/j.1399-0039.1979.tb00815.x
PMID:91216
Abstract

HLA-A and B antigens were defined in 154 unrelated idiopathic hemochromatosis patients. The study confirmed the highly significant positive association with HLA antigens A3 (corrected P less than 10(-10)) and B14 (corrected P less than 10(-9)). HLA-DR typing showed increased frequency of the specificity DRw6, which was frequently associated with the phenotype A3, B14 and antigen B14, suggesting linkage disequilibrium. This was borne out by PLT data.

摘要

相似文献

1
HLA determinants in idiopathic hemochromatosis.
Tissue Antigens. 1979 Jul;14(1):10-4. doi: 10.1111/j.1399-0039.1979.tb00815.x.
2
A study of 609 HLA haplotypes marking for the hemochromatosis gene: (1) mapping of the gene near the HLA-A locus and characters required to define a heterozygous population and (2) hypothesis concerning the underlying cause of hemochromatosis-HLA association.一项针对609个标记血色素沉着症基因的HLA单倍型的研究:(1)该基因在HLA - A位点附近的定位以及定义杂合子群体所需的特征,(2)关于血色素沉着症与HLA关联潜在原因的假说。
Am J Hum Genet. 1987 Aug;41(2):89-105.
3
An HLA-All association with the hemochromatosis allele?HLA与血色素沉着病等位基因存在关联?
Clin Genet. 1983 Sep;24(3):171-6. doi: 10.1111/j.1399-0004.1983.tb02234.x.
4
HLA determinants in 70 Danish patients with idiopathic haemochromatosis.
Clin Genet. 1988 Apr;33(4):286-92. doi: 10.1111/j.1399-0004.1988.tb03450.x.
5
Idiopathic haemochromatosis in the Australian population: HLA linkage and recessivity.澳大利亚人群中的特发性血色素沉着症:HLA连锁与隐性遗传
Hum Immunol. 1981 May;2(3):191-200. doi: 10.1016/0198-8859(81)90011-2.
6
Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis.HLA - A3和HLA - B14抗原与特发性血色素沉着症的关联。
Gut. 1976 May;17(5):332-4. doi: 10.1136/gut.17.5.332.
7
HLA as a marker of the hemochromatosis gene in Sweden.HLA作为瑞典血色素沉着症基因的一个标记。
Hum Genet. 1984;68(1):62-6. doi: 10.1007/BF00293874.
8
Idiopathic hemochromatosis: significance and implications of linkage and association to HLA.
Ann N Y Acad Sci. 1988;526:34-46. doi: 10.1111/j.1749-6632.1988.tb55490.x.
9
Is all genetic (hereditary) hemochromatosis HLA-associated.所有遗传性血色素沉着症都与人类白细胞抗原(HLA)相关吗?
Ann N Y Acad Sci. 1988;526:23-33. doi: 10.1111/j.1749-6632.1988.tb55489.x.
10
Idiopathic haemochromatosis and HLA antigens in Italy: is A3 Bw35 HLA haplotype a marker for idiopathic haemochromatosis gene in north east regions?意大利的特发性血色素沉着症与HLA抗原:A3 Bw35 HLA单倍型是否为意大利东北部地区特发性血色素沉着症基因的一个标志物?
J Clin Pathol. 1986 Feb;39(2):125-8. doi: 10.1136/jcp.39.2.125.

引用本文的文献

1
The role of HLA antigens in disease.人类白细胞抗原(HLA)抗原在疾病中的作用。
Indian J Pediatr. 1980 Sep-Oct;47(388):349-59. doi: 10.1007/BF02759824.
2
Some epistatic two-locus models of disease. I. Relative risks and identity-by-descent distributions in affected sib pairs.一些疾病的上位性双基因座模型。I. 患病同胞对中的相对风险和同源性分布
Am J Hum Genet. 1981 May;33(3):381-95.