Steenbergen Judith N, Casadevall Arturo
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Microbes Infect. 2003 Jun;5(7):667-75. doi: 10.1016/s1286-4579(03)00092-3.
The origin of virulence in environmental fungi that have no requirement for animal hosts in their life cycle is enigmatic. Cryptococcus neoformans is a human pathogenic fungus with virulence factors for mammalian pathogenesis that also contribute to environmental survival. C. neoformans virulence may originate from selection pressures imposed by environmental predators.
在生命周期中对动物宿主无需求的环境真菌中,毒力的起源是个谜。新型隐球菌是一种人类致病真菌,具有用于哺乳动物发病机制的毒力因子,这些因子也有助于其在环境中生存。新型隐球菌的毒力可能源于环境捕食者施加的选择压力。