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人类致病真菌新型隐球菌毒力的起源与维持

The origin and maintenance of virulence for the human pathogenic fungus Cryptococcus neoformans.

作者信息

Steenbergen Judith N, Casadevall Arturo

机构信息

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

出版信息

Microbes Infect. 2003 Jun;5(7):667-75. doi: 10.1016/s1286-4579(03)00092-3.

Abstract

The origin of virulence in environmental fungi that have no requirement for animal hosts in their life cycle is enigmatic. Cryptococcus neoformans is a human pathogenic fungus with virulence factors for mammalian pathogenesis that also contribute to environmental survival. C. neoformans virulence may originate from selection pressures imposed by environmental predators.

摘要

在生命周期中对动物宿主无需求的环境真菌中,毒力的起源是个谜。新型隐球菌是一种人类致病真菌,具有用于哺乳动物发病机制的毒力因子,这些因子也有助于其在环境中生存。新型隐球菌的毒力可能源于环境捕食者施加的选择压力。

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