Isogai Yoh, Tjian Robert
Department of Molecular and Cellular Biology, University of California, Berkeley and Howard Hughes Medical Institute, 401 Barker Hall, Berkeley, CA 94720-3204, USA.
Curr Opin Cell Biol. 2003 Jun;15(3):296-303. doi: 10.1016/s0955-0674(03)00052-8.
With increasingly detailed images of nuclear structures revealed by advanced microscopy, a remarkably compartmentalized cell nucleus has come into focus. Although this complex nuclear organization remains largely unexplored, some progress has been made in deciphering the functional aspects of various subnuclear structures, revealing how this elaborate framework can influence gene activation. Several recent studies have helped illustrate how cells might utilize the nuclear architecture as an additional level of transcriptional control, perhaps by targeting genes and regulatory factors to specific sites within the nucleus that are designated for active RNA synthesis.
随着先进显微镜技术揭示出越来越详细的细胞核结构图像，一个高度分区化的细胞核已成为焦点。尽管这种复杂的核组织在很大程度上仍未被探索，但在解读各种亚核结构的功能方面已取得了一些进展，揭示了这个精巧的框架如何能够影响基因激活。最近的几项研究有助于阐明细胞可能如何利用核结构作为转录控制的额外层面，或许是通过将基因和调控因子靶向细胞核内指定用于活跃RNA合成的特定位点。
