Bourgeau G, McBride B C
Infect Immun. 1976 Apr;13(4):1228-34. doi: 10.1128/iai.13.4.1228-1234.1976.
Streptococcus sanguis and Streptococcus mutans bind to the surface of Actinomyces viscosus, producing large microbial aggregates. Aggregates form rapidly and are not easily dissociated by vigorous mixing. The binding is mediated by dextran. Glucose-grown streptococci will not aggregate unless they are first mixed with high-molecular-weight dextran. Aggregation is induced with dextrans isolated from Leuconostoc, S. sanguis, or S. mutans. Sucrose-grown streptococci will adhere to A. viscosus without the addition of an exogenous source of dextran. A. viscosus will bind dextran and then bind glucose-grown streptococci. Aggregation occurs over a wide pH range and is dependent on cations. The aggregating activity of A. viscosus is both protease and heat sensitive. The aggregating activity of S. sanguis is heat stable but sensitive to dextranase.
血链球菌和变形链球菌与黏性放线菌表面结合，形成大的微生物聚集体。聚集体迅速形成，且不易因剧烈搅拌而解离。这种结合由葡聚糖介导。在葡萄糖中生长的链球菌不会聚集，除非它们首先与高分子量葡聚糖混合。从明串珠菌、血链球菌或变形链球菌中分离出的葡聚糖可诱导聚集。在蔗糖中生长的链球菌在不添加外源葡聚糖的情况下也会黏附于黏性放线菌。黏性放线菌会结合葡聚糖，然后结合在葡萄糖中生长的链球菌。聚集在很宽的pH范围内发生，且依赖于阳离子。黏性放线菌的聚集活性对蛋白酶和热敏感。血链球菌的聚集活性对热稳定，但对葡聚糖酶敏感。
