荧光光学扩散断层扫描。

Fluorescence optical diffusion tomography.

作者信息

Milstein Adam B, Oh Seungseok, Webb Kevin J, Bouman Charles A, Zhang Quan, Boas David A, Millane R P

机构信息

School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907-1285, USA.

出版信息

Appl Opt. 2003 Jun 1;42(16):3081-94. doi: 10.1364/ao.42.003081.

DOI:10.1364/ao.42.003081

PMID:12790460

Abstract

A nonlinear, Bayesian optimization scheme is presented for reconstructing fluorescent yield and lifetime, the absorption coefficient, and the diffusion coefficient in turbid media, such as biological tissue. The method utilizes measurements at both the excitation and the emission wavelengths to reconstruct all unknown parameters. The effectiveness of the reconstruction algorithm is demonstrated by simulation and by application to experimental data from a tissue phantom containing the fluorescent agent Indocyanine Green.

摘要

提出了一种非线性贝叶斯优化方案，用于重建浑浊介质（如生物组织）中的荧光产率和寿命、吸收系数以及扩散系数。该方法利用激发波长和发射波长处的测量值来重建所有未知参数。通过模拟以及将其应用于含有荧光剂吲哚菁绿的组织模型的实验数据，证明了重建算法的有效性。