Gaind Vaibhav, Tsai Hsiao-Rho, Webb Kevin J, Chelvam Venkatesh, Low Philip S
J Opt Soc Am A Opt Image Sci Vis. 2013 Jun 1;30(6):1146-54. doi: 10.1364/JOSAA.30.001146.
Despite the broad impact in medicine that optics can bring, thus far practical approaches are limited to weak scatter or near-surface monitoring. We show a method that utilizes a laser topography scan and a diffusion equation model to describe the photon transport, together with a multiresolution unstructured grid solution to the nonlinear optimization measurement functional, that overcomes these limitations. We conclude that it is possible to achieve whole body optical imaging with a resolution suitable for finding cancer nodules within an organ during surgery, with the aid of a targeted imaging agent.
尽管光学在医学领域能产生广泛影响，但到目前为止，实际应用方法仅限于弱散射或近表面监测。我们展示了一种方法，该方法利用激光地形扫描和扩散方程模型来描述光子传输，并结合对非线性优化测量函数的多分辨率非结构化网格求解，从而克服了这些限制。我们得出结论，借助靶向成像剂，有可能实现全身光学成像，其分辨率足以在手术期间发现器官内的癌结节。
