环 closing metathesis 在肽中的结构和药理效应。

Structural and pharmacological effects of ring-closing metathesis in peptides.

机构信息

School of Pharmacy, University of Oslo, Oslo, Norway.

出版信息

Molecules. 2010 Sep 21;15(9):6638-77. doi: 10.3390/molecules15096638.

DOI:10.3390/molecules15096638

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6257744/

Abstract

Applications of ring-closing alkene metathesis (RCM) in acyclic α- and β-peptides and closely related systems are reviewed, with a special emphasis on the structural and pharmacological effects of cyclization by RCM.

摘要

综述了闭环烯键复分解（RCM）在非环 α-和 β-肽及相关体系中的应用，特别强调了 RCM 环化的结构和药理学效应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/754a/6257744/3da2a0a9f000/molecules-15-06638-g001.jpg

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