吉米沙星及其他抗菌药物对肺炎支原体的抑制和杀菌活性。
Inhibitory and bactericidal activities of gemifloxacin and other antimicrobials against Mycoplasma pneumoniae.
作者信息
Waites Ken B, Crabb Donna M, Duffy Lynn B
机构信息
Department of Pathology, WP 230, University of Alabama at Birmingham, 619n 19th Street South, Birmingham, AL 35249, USA.
出版信息
Int J Antimicrob Agents. 2003 Jun;21(6):574-7. doi: 10.1016/s0924-8579(03)00060-8.
The MIC of gemifloxacin was compared with that of sparfloxacin, levofloxacin, moxifloxacin, gatifloxacin, ciprofloxacin, doxycycline, erythromycin, azithromycin and clarithromycin using 97 clinical isolates of Mycoplasma pneumoniae. MBCs of fluoroquinolones were determined for a subgroup of 12 isolates. Macrolides were the most potent agents with MIC(90)s for all drugs <or=0.001 mg/l. The doxycycline MIC(90) was 0.5 mg/l. Gemifloxacin MICs ranged from <or=0.001 to 0.25 mg/l. The gemifloxacin MIC(90) (0.125 mg/l) was equivalent to moxifloxacin and gatifloxacin, was 2-fold lower than sparfloxacin, 8-fold lower than levofloxacin and 32-fold lower than ciprofloxacin. MBCs for gemifloxacin were predominantly within 2-4 times the corresponding MIC values, indicating a bactericidal effect.
使用97株肺炎支原体临床分离株，比较了吉米沙星与司帕沙星、左氧氟沙星、莫西沙星、加替沙星、环丙沙星、多西环素、红霉素、阿奇霉素和克拉霉素的最低抑菌浓度（MIC）。对12株分离株的亚组测定了氟喹诺酮类药物的最低杀菌浓度（MBC）。大环内酯类是最有效的药物，所有药物的MIC（90）≤0.001mg/L。多西环素的MIC（90）为0.5mg/L。吉米沙星的MIC范围为≤0.001至0.25mg/L。吉米沙星的MIC（90）（0.125mg/L）与莫西沙星和加替沙星相当，比司帕沙星低2倍，比左氧氟沙星低8倍，比环丙沙星低32倍。吉米沙星的MBC主要在相应MIC值的2至4倍范围内，表明具有杀菌作用。
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