Kelly-Welch Ann E, Hanson Erica M, Boothby Mark R, Keegan Achsah D
Department of Immunology, Holland Laboratory, American Red Cross, Rockville, MD 20855, and the Institute for Biomedical Sciences, George Washington Medical Center, Washington, DC 20037, USA.
Science. 2003 Jun 6;300(5625):1527-8. doi: 10.1126/science.1085458.
Cytokines are inflammatory mediators important in responding to pathogens and other foreign challenges. Interleukin-4 (IL-4) and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. In addition to their physiological roles, these cytokines are also implicated in pathological conditions such as asthma and allergy. IL-4 can stimulate two receptors, type I and type II, whereas IL-13 signaling is mediated only by the type II receptor (see the STKE Connections Maps). These cytokines activate the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascades, which may contribute to allergic responses. In addition, stimulation of the phosphatidylinositol 3-kinase (PI3K) pathway through recruitment of members of the insulin receptor substrate family may contribute to survival and proliferation.
细胞因子是对病原体和其他外来挑战做出反应时起重要作用的炎症介质。白细胞介素-4（IL-4）和IL-13是由2型辅助性T细胞、肥大细胞和嗜碱性粒细胞产生的两种细胞因子。除了其生理作用外，这些细胞因子还与哮喘和过敏等病理状况有关。IL-4可刺激I型和II型两种受体，而IL-13信号传导仅由II型受体介导（见STKE连接图谱）。这些细胞因子激活Janus激酶/信号转导子和转录激活子（JAK/STAT）信号级联反应，这可能导致过敏反应。此外，通过募集胰岛素受体底物家族成员来刺激磷脂酰肌醇3激酶（PI3K）途径可能有助于细胞存活和增殖。
