Chatila Talal A
Department of Pediatrics, The David Geffen School of Medicine at the University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095-1752, USA.
Trends Mol Med. 2004 Oct;10(10):493-9. doi: 10.1016/j.molmed.2004.08.004.
Asthma is a chronic allergic inflammatory disease, the initiation and progression of which is dependent on the cytokines interleukin (IL)-4 and IL-13 acting through related receptor complexes. Disease pathogenesis is effected by intracellular signaling pathways that couple primarily to specific motifs within the intracellular domain of the IL-4 receptor alpha chain (IL-4Ralpha), a subunit that is common to the IL-4 and IL-13 receptor complexes. Recent studies using genetic approaches have identified distinct functions for the respective IL-4Ralpha-coupled signaling pathways in regulating both early and chronic stages of asthma. Polymorphisms in components of the IL-4 and IL-13 cytokine-receptor axes are associated with allergy and asthma, suggesting that variations among individuals in the activity of this pathway contribute to disease susceptibility and manifestations.
哮喘是一种慢性过敏性炎症性疾病，其发病和进展依赖于细胞因子白细胞介素（IL）-4和IL-13通过相关受体复合物发挥作用。疾病发病机制受细胞内信号通路影响，这些信号通路主要与IL-4受体α链（IL-4Rα）细胞内结构域内的特定基序偶联，IL-4Rα是IL-4和IL-13受体复合物共有的一个亚基。最近使用基因方法的研究已经确定了各自与IL-4Rα偶联的信号通路在调节哮喘早期和慢性阶段的不同功能。IL-4和IL-13细胞因子受体轴成分的多态性与过敏和哮喘相关，这表明该通路活性在个体间的差异导致了疾病易感性和临床表现。
