Vaudry David, Falluel-Morel Anthony, Leuillet Sébastien, Vaudry Hubert, Gonzalez Bruno J
European Institute for Peptide Research (IFRMP 23), Laboratoryof Cellular and Molecular Neuroendocrinology, INSERM U413, University of Rouen, 76821 Mont-Saint-Aignan, France.
Science. 2003 Jun 6;300(5625):1532-4. doi: 10.1126/science.1085260.
The proper development of the central nervous system depends upon a finely tuned balance between cell proliferation and programmed cell death (PCD). Although PCD was initially believed to depend solely on the inability of certain neurons to obtain access to a limited supply of trophic factors, it has become apparent that the local production of death signals is also critical. In this Viewpoint, we discuss several pathways implicated in the survival of cerebellar granule cells- both pathways that protect from apoptosis and pathways that promote apoptosis-and describe how these disparate pathways converge on the final common mediators of PCD. Information on other important pathways implicated in granule cell survival may be found in the Connections Maps.
中枢神经系统的正常发育取决于细胞增殖和程序性细胞死亡（PCD）之间精确调节的平衡。虽然最初认为PCD仅取决于某些神经元无法获得有限的营养因子供应，但现在已经明显，死亡信号的局部产生也至关重要。在本观点中，我们讨论了与小脑颗粒细胞存活相关的几种途径——既包括保护细胞免受凋亡的途径，也包括促进凋亡的途径——并描述了这些不同的途径如何汇聚到PCD的最终共同介导因子上。关于颗粒细胞存活中涉及的其他重要途径的信息可在连接图中找到。
