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脑内活性精细调控的机制：垂体腺苷酸环化酶激活肽受体 PAC1 的可变剪接。

Alternative Splicing of the Pituitary Adenylate Cyclase-Activating Polypeptide Receptor PAC1: Mechanisms of Fine Tuning of Brain Activity.

机构信息

Department of Molecular Cell Biology, Weizmann Institute of Science Rehovot, Israel.

出版信息

Front Endocrinol (Lausanne). 2013 May 21;4:55. doi: 10.3389/fendo.2013.00055. eCollection 2013.

DOI:10.3389/fendo.2013.00055
PMID:23734144
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3659299/
Abstract

Alternative splicing of the precursor mRNA encoding for the neuropeptide receptor PAC1/ADCYAP1R1 generates multiple protein products that exhibit pleiotropic activities. Recent studies in mammals and zebrafish have implicated some of these splice isoforms in control of both cellular and body homeostasis. Here, we review the regulation of PAC1 splice variants and their underlying signal transduction and physiological processes in the nervous system.

摘要

前体 mRNA 的可变剪接生成了编码神经肽受体 PAC1/ADCYAP1R1 的多种蛋白产物，这些产物具有多种活性。最近在哺乳动物和斑马鱼中的研究表明，这些剪接异构体中的一些参与了细胞和全身内稳态的控制。本文综述了 PAC1 剪接变体的调控及其在神经系统中的信号转导和生理过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cdf/3659299/114e91de74a4/fendo-04-00055-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cdf/3659299/114e91de74a4/fendo-04-00055-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cdf/3659299/4d607e1279d0/fendo-04-00055-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cdf/3659299/746e5b8fa69c/fendo-04-00055-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cdf/3659299/b23e45ff2099/fendo-04-00055-g003.jpg
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