[慢性肝病患者肝细胞癌与丙型肝炎病毒感染关系的临床研究]

[Clinical study on relationship between hepatocellular carcinoma and hepatitis C virus infection in patients with chronic liver disease].

作者信息

Sata M, Tokeshi S, Nakano H, Majima Y, Tanikawa K

机构信息

2nd Department of Internal Medicine, Kurume University School of Medicine.

出版信息

Rinsho Byori. 1992 Sep;40(9):929-34.

PMID:1279247

Abstract

The relationship between hepatocellular carcinoma (HCC) and hepatitis C virus (HCV) infection was investigated. Antibody to hepatitis C virus was detected in 88.8% and 87.0% of 240 patients with hepatocellular carcinoma and liver cirrhosis, respectively. A history of blood transfusion was shown in only 21.8% (21/96) of the HCV antibody positive HCC patients. Of 196 patients with chronic hepatitis type C and the HCV antibody positive liver cirrhosis, 10 developed HCC during the follow-up period of two years. A high prevalence of HCV antibody was also shown among 83 patients with alcoholic liver cirrhosis and HCC associated with alcoholic liver cirrhosis. HCV-RNA was detected in all patients with alcoholic HCC. These data support a causal association between hepatitis C virus and hepatocellular carcinoma.

摘要

对肝细胞癌（HCC）与丙型肝炎病毒（HCV）感染之间的关系进行了研究。在240例肝细胞癌患者和肝硬化患者中，分别有88.8%和87.0%检测到丙型肝炎病毒抗体。在HCV抗体阳性的HCC患者中，仅有21.8%（21/96）有输血史。在196例慢性丙型肝炎患者和HCV抗体阳性的肝硬化患者中，有10例在两年的随访期内发生了HCC。在83例酒精性肝硬化患者以及与酒精性肝硬化相关的HCC患者中，HCV抗体的患病率也很高。在所有酒精性HCC患者中均检测到HCV-RNA。这些数据支持丙型肝炎病毒与肝细胞癌之间存在因果关联。