Nishimura Y, Usui H, Suzuki A, Kajimoto N, Yamanishi Y
Department of Pharmacology, Kinki University School of Medicine, Osaka, Japan.
Jpn J Pharmacol. 1992 Jul;59(3):333-8. doi: 10.1254/jjp.59.333.
The relaxant effects of calcitonin gene-related peptide (CGRP) and other drugs were compared in basilar artery rings obtained from stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto rats (WKY). In addition, the relaxant effect of CGRP on basilar arteries from spontaneously hypertensive rats (SHR) was examined. Relaxation induced by CGRP was independent of the presence of endothelium, and it was markedly increased in SHRSP when compared to WKY. In contrast, acetylcholine-induced relaxation was endothelium-dependent and did not differ between the two groups. Enhanced CGRP-induced relaxation was also found in SHR when compared to WKY. However, the relaxant response was greater in SHRSP than in SHR. No significant differences were found in the relaxation induced by isoproterenol, forskolin, dibutyryl cyclic AMP, and 3-isobutyl-1-methylxanthine in endothelium-rubbed arteries of WKY and SHRSP. These results suggest that CGRP produces endothelium-independent relaxation in the rat basilar artery, and that the enhanced CGRP-induced relaxation found in SHRSP may not be associated with alterations of vasodilation mediated by cyclic AMP.
在取自易患中风的自发性高血压大鼠（SHRSP）和Wistar-Kyoto大鼠（WKY）的基底动脉环中，比较了降钙素基因相关肽（CGRP）和其他药物的舒张作用。此外，还研究了CGRP对自发性高血压大鼠（SHR）基底动脉的舒张作用。CGRP诱导的舒张与内皮的存在无关，与WKY相比，SHRSP中该舒张作用明显增强。相反，乙酰胆碱诱导的舒张依赖于内皮，两组之间无差异。与WKY相比，SHR中也发现CGRP诱导的舒张增强。然而，SHRSP中的舒张反应比SHR中的更大。在WKY和SHRSP的内皮剥脱动脉中，异丙肾上腺素、福斯可林、二丁酰环磷腺苷和3-异丁基-1-甲基黄嘌呤诱导的舒张无显著差异。这些结果表明，CGRP在大鼠基底动脉中产生不依赖于内皮的舒张作用，并且在SHRSP中发现的CGRP诱导的舒张增强可能与环磷腺苷介导的血管舒张改变无关。
