Tomobe Y I, Ishikawa T, Goto K
Department of Pharmacology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.
Eur J Pharmacol. 1998 Jun 26;351(3):351-5. doi: 10.1016/s0014-2999(98)00379-3.
In isolated superior mesenteric arteries, vasodilation induced by calcitonin gene-related peptide (CGRP) was significantly larger in 12-week-old spontaneously hypertensive rats (SHR) than Wistar-Kyoto rats (WKY). In WKY and 6-week-old SHR, most of the vasodilator response to CGRP was abolished by Nw-nitro-L-arginine and indomethacin. In contrast, the inhibitors caused no significant change in the response in 12-week-old SHR. Vasodilations induced by acetylcholine and isoproterenol were smaller in 12-week-old SHR than WKY, and that induced by sodium nitroprusside was comparable in both tissues. These results suggest that endothelium-independent vasodilator activity of CGRP is enhanced in hypertensive SHR, which overwhelms the decreased endothelium-dependent effects.
在分离的肠系膜上动脉中，降钙素基因相关肽（CGRP）诱导的血管舒张在12周龄自发性高血压大鼠（SHR）中比Wistar-Kyoto大鼠（WKY）显著更大。在WKY和6周龄的SHR中，对CGRP的大多数血管舒张反应被Nw-硝基-L-精氨酸和吲哚美辛消除。相比之下，这些抑制剂在12周龄的SHR中对反应没有显著影响。乙酰胆碱和异丙肾上腺素诱导的血管舒张在12周龄的SHR中比WKY小，而硝普钠诱导的血管舒张在两种组织中相当。这些结果表明，高血压SHR中CGRP的非内皮依赖性血管舒张活性增强，这超过了内皮依赖性效应的降低。
