Demir Başaran, Uluğ Berna
Hacettepe U Tip Fak, Psikiyatri AD, Ankara.
Turk Psikiyatri Derg. 2002 Spring;13(1):15-21.
To compare late and early onset alcoholism with regard to neurocognitive functions.
Using the age of alcoholism onset as a criterion, 20 late onset and 14 early onset male alcoholics were included in the study. Eleven healthy male volunteers with similar demographic features were included as a control group. Alcohol and drug modules of Schedules for clinical Assessment in Neuropsychiatry (SCAN) were administered to each subject in order to gather data on alcohol intake variables. The life time severity of drinking problems was assessed by the Michigan Alcoholism Screening Test (MAST). All patients met the diagnostic criteria of ICD-10 for alcohol dependence. The neuropsychological battery consisted of the Wisconsin Card Sorting Test, the Wechsler Memory Scale and Word Fluency Tests. The battery was administered to each patient 15 days after their entry into detoxification programme when the withdrawal syndrome ceased and all the psychotropic medications stopped for at least 1 week.
Compared with the control group, both groups of alcoholic patients displayed impairment in frontal lobe functions and memory. Neuropsychological test performance did not differ between early and late onset groups.
The results of this study suggest that subtypes of alcoholism based on a one-dimensional clinical application of Cloninger's typology are not associated with discriminatively different patterns of neuropsychological abnormalities.
比较迟发性和早发性酒精中毒患者的神经认知功能。
以酒精中毒发病年龄为标准，本研究纳入了20例迟发性男性酒精中毒患者和14例早发性男性酒精中毒患者。选取11名具有相似人口统计学特征的健康男性志愿者作为对照组。对每位受试者进行神经精神病临床评定量表（SCAN）中的酒精与药物模块测试，以收集酒精摄入变量的数据。采用密歇根酒精中毒筛查测试（MAST）评估饮酒问题的终生严重程度。所有患者均符合国际疾病分类第10版（ICD - 10）中酒精依赖的诊断标准。神经心理成套测验包括威斯康星卡片分类测验、韦氏记忆量表和词语流畅性测验。在患者进入戒毒项目15天后，当戒断综合征消失且所有精神药物停用至少1周时，对每位患者进行该成套测验。
与对照组相比，两组酒精中毒患者均表现出额叶功能和记忆受损。早发性和迟发性酒精中毒组之间的神经心理测试表现无差异。
本研究结果表明，基于克隆宁格类型学的一维临床应用所划分的酒精中毒亚型，与具有显著差异的神经心理异常模式无关。
