Marrs Joyce, Newton Susan
Clin J Oncol Nurs. 2003 May-Jun;7(3):299-303. doi: 10.1188/03.CJON.299-303.
Peripheral neuropathy is a condition that can be caused or exacerbated by the administration of certain chemotherapeutic agents. The effects of chemotherapy-induced peripheral neuropathy (CIPN) are dose limiting and might lead to permanent, debilitating disabilities. Oncology nurses should be aware of the impact of CIPN. Nurses should be cognizant of the pathophysiology, pre-existing conditions contributing to an increased risk of CIPN, causative agents, and interventions used in managing CIPN. Awareness that the peripheral nervous system is divided into small fibers, large fibers, and the autonomic nervous system is important in the assessment, detection, and treatment of CIPN. Presenting symptoms are related to the specific fibers that are damaged. Because of the different mechanisms of action, CIPN symptoms vary depending on the chemotherapeutic agents used. This article provides a general overview of CIPN, including pathophysiology, causes, risk factors, assessment, and current treatment. Oncology nurses must be alert for the manifestations of CIPN. Early intervention and patient education can have a positive effect on the quality of life for patients with this disorder.
周围神经病变是一种可能由某些化疗药物的使用引起或加重的病症。化疗引起的周围神经病变（CIPN）的影响具有剂量限制性，可能导致永久性的、使人衰弱的残疾。肿瘤学护士应了解CIPN的影响。护士应认识到CIPN的病理生理学、导致CIPN风险增加的既往病症、致病因素以及用于管理CIPN的干预措施。认识到周围神经系统分为小纤维、大纤维和自主神经系统，这对CIPN的评估、检测和治疗很重要。出现的症状与受损的特定纤维有关。由于作用机制不同，CIPN症状因所用化疗药物而异。本文提供了CIPN的概述，包括病理生理学、病因、危险因素、评估和当前治疗方法。肿瘤学护士必须警惕CIPN的表现。早期干预和患者教育对患有这种疾病的患者的生活质量可产生积极影响。
