Visovsky Constance, Collins Mary, Abbott Linda, Aschenbrenner Julie, Hart Connie
The College of Nursing, The University of Nebraska Medical Center, Omaha, NE, USA.
Clin J Oncol Nurs. 2007 Dec;11(6):901-13. doi: 10.1188/07.CJON.901-913.
Chemotherapy-induced peripheral neuropathy (CIPN) continues to be a significant, debilitating symptom resulting from the administration of neurotoxic chemotherapy for the treatment of cancer. CIPN is an important consequence of cancer treatment because of its potential impact on physical functioning and quality of life. Oncology nurses play an important role in assessing, monitoring, and educating clients about CIPN. Despite investigations concerning pharmacologic and nonpharmacologic approaches to either preventing or minimizing the neurotoxicity resulting from certain chemotherapeutic agents, evidence to support the interventions is lacking. This article presents information concerning CIPN and summarizes the evidence for pharmacologic and nonpharmacologic approaches to the prevention and treatment of CIPN.
化疗引起的周围神经病变（CIPN）仍然是因使用神经毒性化疗药物治疗癌症而导致的一种严重且使人衰弱的症状。由于CIPN对身体功能和生活质量有潜在影响，它是癌症治疗的一个重要后果。肿瘤护理人员在评估、监测CIPN以及对患者进行相关教育方面发挥着重要作用。尽管针对预防或尽量减少某些化疗药物所致神经毒性的药物和非药物方法进行了研究，但支持这些干预措施的证据仍然不足。本文介绍了有关CIPN的信息，并总结了预防和治疗CIPN的药物及非药物方法的证据。
