Department of Medicine, Olabisi Onabanjo University Teaching Hospital, Ibadan, Oyo State, Nigeria.
J Natl Med Assoc. 2003 May;95(5):344-9.
Significant asymptomatic bacteriuria is a risk factor for symptomatic urinary infection and septicemia among predisposed individuals such as diabetics. We investigated the pattern of asymptomatic bacteriuria among our type 2 diabetics with a view to documenting the prevalence, type of organisms responsible and the antibiotic susceptibility pattern. One hundred and twenty-four type 2 Nigerian diabetics (55 males and 69 females) submitted midstream urine specimens for culture. Thirty-three patients had significant bacteriuria (9 males and 24 females), showing the frequency of occurrence of asymptomatic bacteriuria to be 26.6%. The most common organism isolated was Klebsiella pneumonia at 42.4%. Gram-negative bacilli made up about 23 (69.7%) of the isolates. Isolates were poorly sensitive to the readily available antibiotics (ampicillin, tetracycline and cotrimoxazole), but a large number of the organisms isolated were sensitive to nitrofurantoin, gentamicin, ciprofloxacin and ofloxacin. Sensitivity to erythromycin, nalidixic acid and cefuroxime was moderate. Asymptomatic bacteriuria is, thus, more prevalent among the Nigerian diabetic population than in the non-diabetics. A changing pattern of disease is observed with Klebsiella sp. now accounting for the majority of asymptomatic bacteriuria among diabetics. The organisms are not sensitive to the commonly available antibacterial agents.
无症状菌尿是易患人群（如糖尿病患者）发生症状性尿路感染和败血症的危险因素。我们调查了我们 2 型糖尿病患者中无症状菌尿的模式，旨在记录其患病率、致病生物体的类型以及抗生素敏感性模式。124 名尼日利亚 2 型糖尿病患者（55 名男性和 69 名女性）提交了中段尿液样本进行培养。33 名患者有明显的菌尿（9 名男性和 24 名女性），无症状菌尿的发生率为 26.6%。最常见的分离菌是肺炎克雷伯菌，占 42.4%。革兰氏阴性杆菌约占 23 株（69.7%）。分离株对现有抗生素（氨苄西林、四环素和复方新诺明）的敏感性较差，但大量分离株对呋喃妥因、庆大霉素、环丙沙星和氧氟沙星敏感。对红霉素、萘啶酸和头孢呋辛的敏感性适中。因此，无症状菌尿在尼日利亚糖尿病患者中的流行率高于非糖尿病患者。观察到疾病模式的变化，克雷伯菌属现在占糖尿病患者无症状菌尿的大多数。这些生物体对常用的抗菌药物不敏感。
