Shekhar Malathy P V, Pauley Robert, Heppner Gloria
Breast Cancer Program, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA.
Breast Cancer Res. 2003;5(3):130-5. doi: 10.1186/bcr580. Epub 2003 Feb 20.
Epithelial-mesenchymal interactions play an important role both in normal mammary gland development and during neoplastic transformation. Perturbations in the production, deposition and degradation of the extracellular matrix occurring during neoplastic transformation and progression have been implicated to arise from alterations in the stromal response. These changes in the stroma exhibit a dominant regulatory role, via microenvironmental epigenetic effectors, to contribute to the development of the tumorigenic epithelial phenotype. The role of stromally derived microenvironmental epigenetic effectors in modulating epithelial growth, hormonal response, morphogenesis and epithelial plasticity is discussed.
上皮-间质相互作用在正常乳腺发育和肿瘤转化过程中均发挥着重要作用。肿瘤转化和进展过程中发生的细胞外基质产生、沉积和降解的扰动被认为源于基质反应的改变。基质中的这些变化通过微环境表观遗传效应物发挥主导调节作用,促进致瘤上皮表型的发展。本文讨论了基质衍生的微环境表观遗传效应物在调节上皮生长、激素反应、形态发生和上皮可塑性方面的作用。