乳腺成纤维细胞通过机械和旁分泌信号调节正常和致瘤性乳腺上皮细胞的形态发生。
Mammary fibroblasts regulate morphogenesis of normal and tumorigenic breast epithelial cells by mechanical and paracrine signals.
机构信息
Department of Gynecology and Obstetrics, University Medical Center Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany.
出版信息
Cancer Lett. 2012 Dec 28;325(2):175-88. doi: 10.1016/j.canlet.2012.06.014. Epub 2012 Jul 7.
Abstract
Stromal factors play a critical role in the development of the mammary gland. Using a three dimensional-coculture model we demonstrate a significant role for stromal fibroblasts in the regulation of normal mammary epithelial morphogenesis and the control of tumor growth. Both soluble factors secreted by fibroblasts and fibroblast-derived modifications of the matrix compliance contribute to the regulation of epithelial cell morphogenesis. Readjustment of matrix tension by fibroblasts can even induce a phenotypic reversion of breast carcinoma cells. These data offer a basis to develop new strategies for the normalization of the tumor stroma as an innovative target in cancer therapy.
摘要
基质因子在乳腺的发育中起着关键作用。我们使用三维共培养模型证明了基质成纤维细胞在调节正常乳腺上皮形态发生和控制肿瘤生长方面的重要作用。成纤维细胞分泌的可溶性因子和纤维母细胞衍生的基质顺应性改变都有助于调节上皮细胞的形态发生。成纤维细胞重新调整基质张力甚至可以诱导乳腺癌细胞的表型逆转。这些数据为开发新的策略提供了基础，将肿瘤基质的正常化作为癌症治疗的一个创新靶点。
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