Izzo Francesco
G. Pascale National Cancer Institute, Naples, Italy.
Ann Surg Oncol. 2003 Jun;10(5):491-7. doi: 10.1245/aso.2003.07.016.
Thermal ablation of hepatic malignancies is becoming a widespread treatment approach. In addition to radiofrequency ablation, microwave coagulation (MCT) and laser-induced interstitial thermotherapy (LITT) are being used clinically to treat patients with liver cancers.
The principles and clinical indications for MCT and LITT are described. Treatment approaches and results from published clinical studies are reviewed. The evolution of these thermal treatment modalities and limitations of currently available equipment is provided.
The interstitial probes and equipment used for MCT and LITT for liver tumors are undergoing changes to improve treatment efficacy. Both MCT and LITT have been limited by the relatively small zone of coagulation produced with a single probe placement. Both techniques can be performed safely, and local recurrence and long-term survival rates are being established.
MCT and LITT are two alternative thermal ablation techniques being used to treat patients with primary and metastatic hepatic malignancies. The utility of these two treatments has been limited by the relatively small area of thermal necrosis produced around the interstitial probes, but design modifications and new equipment may improve these limitations.
肝脏恶性肿瘤的热消融正成为一种广泛应用的治疗方法。除了射频消融外，微波凝固治疗（MCT）和激光诱导间质热疗（LITT）也正在临床上用于治疗肝癌患者。
描述了MCT和LITT的原理及临床适应证。回顾了已发表临床研究的治疗方法和结果。介绍了这些热治疗方式的发展以及现有设备的局限性。
用于肝脏肿瘤MCT和LITT的间质探头及设备正在改进以提高治疗效果。MCT和LITT均受限于单次探头放置产生的相对较小的凝固区域。两种技术均可安全实施，局部复发率和长期生存率正在确定中。
MCT和LITT是用于治疗原发性和转移性肝脏恶性肿瘤患者的两种替代性热消融技术。这两种治疗方法的效用受到间质探头周围产生的相对较小的热坏死区域的限制，但设计改进和新设备可能改善这些局限性。
