癌症的激光消融：过去、现在与未来

Schena Emiliano, Saccomandi Paola, Fong Yuman

Unit of Measurements and Biomedical Instrumentation, Center for Integrated Research, Università Campus Bio-Medico di Roma, Via Álvaro del Portillo, 21, Rome 00128, Italy.

IHU (Institute of Image-Guided Surgery), S/c Ircad, Strasbourg 67091, France.

J Funct Biomater. 2017 Jun 14;8(2):19. doi: 10.3390/jfb8020019.

Laser ablation (LA) is gaining acceptance for the treatment of tumors as an alternative to surgical resection. This paper reviews the use of lasers for ablative and surgical applications. Also reviewed are solutions aimed at improving LA outcomes: hyperthermal treatment planning tools and thermometric techniques during LA, used to guide the surgeon in the choice and adjustment of the optimal laser settings, and the potential use of nanoparticles to allow biologic selectivity of ablative treatments. Promising technical solutions and a better knowledge of laser-tissue interaction should allow LA to be used in a safe and effective manner as a cancer treatment.

激光消融（LA）作为手术切除的替代方法，在肿瘤治疗中越来越被接受。本文综述了激光在消融和手术应用中的使用情况。还综述了旨在改善激光消融效果的解决方案：激光消融期间的高温治疗规划工具和测温技术，用于指导外科医生选择和调整最佳激光设置，以及纳米颗粒在实现消融治疗生物选择性方面的潜在用途。有前景的技术解决方案以及对激光与组织相互作用的更深入了解，应能使激光消融作为一种癌症治疗方法安全有效地应用。