McParland Brent E, Macklem Peter T, Pare Peter D
McDonald Research Laboratory/The iCAPTURE Center, St Paul's Hospital, University of British Columbia, Vancouver, Canada V6Z 1Y6.
J Appl Physiol (1985). 2003 Jul;95(1):426-34. doi: 10.1152/japplphysiol.00159.2003.
Airway wall remodeling is well documented for asthmatic airways and is believed to result from chronic and/or short-term exposure to inflammatory stimuli. Airway wall remodeling can contribute to airway narrowing as well as to the airway hyperresponsiveness, which is a characteristic abnormality in asthma. However, the potential for airway narrowing could be much worse if it were not for some of the protective effects of remodeling that may help to limit airway narrowing in asthmatic patients. This minireview discusses the evidence for airway wall remodeling and its effects, friend and/or foe, on airway narrowing in asthmatic patients.
气道壁重塑在哮喘气道中已有充分记录，被认为是长期和/或短期暴露于炎症刺激的结果。气道壁重塑可导致气道狭窄以及气道高反应性，这是哮喘的一个特征性异常。然而，如果没有重塑的一些保护作用，气道狭窄的可能性可能会更严重，这些保护作用可能有助于限制哮喘患者的气道狭窄。本综述讨论了气道壁重塑的证据及其对哮喘患者气道狭窄的影响，无论是有利还是有弊。
