血栓素拮抗作用与慢性支气管炎中的咳嗽
Thromboxane antagonism and cough in chronic bronchitis.
作者信息
Ishiura Yoshihisa, Fujimura Masaki, Yamamori Chihiro, Nobata Kouichi, Myou Shigeharu, Kurashima Kazuyoshi, Takegoshi Tadayoshi
机构信息
The Division of Pulmonary Medicine, Wajima Municipal Hospital, Wajima, Japan.
出版信息
Ann Med. 2003;35(2):135-9. doi: 10.1080/07853890310010032.
BACKGROUND
The increased eicosanoid synthesis has been suggested as the underlying mechanism of chronic productive cough in patients with chronic bronchitis.
METHOD
The effects of the orally active thromboxane A2 (TxA2) receptor antagonist seratrodast and the cysteinyl leukotrienes (cLTs) receptor antagonist pranlukast on cough response to inhaled capsaicin were examined in sixteen patients with stable chronic bronchitis. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough sensitivity.
RESULTS
The cough threshold was significantly increased compared with placebo after four-week treatment with seratrodast, but not after treatment with pranlukast.
CONCLUSIONS
TxA2, but not cLTs, may be a possible modulator augmenting airway cough sensitivity in chronic bronchitis. Thromboxane antagonism may be considered to be one of the therapeutic options for the treatment of chronic productive cough.
背景
类花生酸合成增加被认为是慢性支气管炎患者慢性咳痰性咳嗽的潜在机制。
方法
在16例稳定期慢性支气管炎患者中，研究了口服活性血栓素A2（TxA2）受体拮抗剂塞曲司特和半胱氨酰白三烯（cLTs）受体拮抗剂普仑司特对吸入辣椒素咳嗽反应的影响。辣椒素咳嗽阈值定义为引起5次或更多次咳嗽的辣椒素最低浓度，以此作为气道咳嗽敏感性指标进行测量。
结果
塞曲司特治疗4周后，与安慰剂相比咳嗽阈值显著升高，但普仑司特治疗后未出现此情况。
结论
TxA2而非cLTs可能是增强慢性支气管炎气道咳嗽敏感性的潜在调节因子。血栓素拮抗作用可被视为治疗慢性咳痰性咳嗽的治疗选择之一。
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