环氧化酶-2在鼻窦支气管综合征患者对吸入辣椒素咳嗽反射敏感性中的作用。
Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome.
作者信息
Ishiura Yoshihisa, Fujimura Masaki, Yamamoto Hiroki, Ohkura Noriyuki, Myou Shigeharu
机构信息
The Department of Internal Medicine, Toyama City Hospital, Toyama, Japan.
出版信息
Cough. 2010 Aug 9;6:7. doi: 10.1186/1745-9974-6-7.
BACKGROUND
Sinobronchial syndrome is a cause of chronic productive cough. Inflammatory mediators are involved in the pathophysiology of chronic productive cough. Accumulating evidences indicate that cyclooxygenase (COX)-2, one of the inducible isoforms of COX, is a key element in the pathophysiological process of a number of inflammatory disorders. However, little is known about the role of COX-2 in chronic productive cough in patients with sinobronchial syndrome known as neutrophilic bronchial inflammation.
METHODS
The effect of etodolac, a potent COX-2 inhibitor, on cough response to inhaled capsaicin was examined in 15 patients with sinobronchial syndrome in a randomized, placebo-controlled cross-over study. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough reflex sensitivity.
RESULTS
The cough threshold was significantly (p < 0.03) increased after two-week treatment with etodolac (200 mg twice a day orally) compared with placebo [37.5 (GSEM 1.3) vs. 27.2 (GSEM 1.3) muM].
CONCLUSIONS
These findings indicate that COX-2 may be a possible modulator augmenting airway cough reflex sensitivity in patients with sinobronchial syndrome.
背景
鼻支气管综合征是慢性咳痰性咳嗽的一个病因。炎症介质参与慢性咳痰性咳嗽的病理生理过程。越来越多的证据表明，环氧化酶（COX）-2作为COX的诱导型同工酶之一，在多种炎症性疾病的病理生理过程中是一个关键因素。然而，关于COX-2在以嗜中性粒细胞性支气管炎为特征的鼻支气管综合征患者慢性咳痰性咳嗽中的作用，人们知之甚少。
方法
在一项随机、安慰剂对照的交叉研究中，对15例鼻支气管综合征患者，检测了强效COX-2抑制剂依托度酸对吸入辣椒素咳嗽反应的影响。辣椒素咳嗽阈值定义为引起5次或更多次咳嗽的辣椒素最低浓度，作为气道咳嗽反射敏感性的指标进行测量。
结果
与安慰剂相比，依托度酸（每日口服2次，每次200mg）治疗2周后，咳嗽阈值显著升高（p<0.03）[37.5（总体标准误1.3）对27.2（总体标准误1.3）μM]。
结论
这些发现表明，COX-2可能是鼻支气管综合征患者气道咳嗽反射敏感性增强的一个潜在调节因子。
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