Chakmakjian Z H, Abraham G E
Obstet Gynecol. 1975 Nov;46(5):544-8.
The peripheral levels of pregnenolone (delta5-P), 17-hydroxypregnenolone (17-delta5-P), progesterone (P), 17-hydroxyprogesterone (17-P), testosterone (T), 5alpha-dihydrotestosterone (DHT), androstenedione (A), dehydroepiandrosterone (DHEA), its sulfate (DHEA-S), estrone (E1), estradiol-17beta (E2), and cortisol (F) were measured prior to and 1 1/2 and 9 months after removal of a right adrenal "compact cell" adenoma in an amenorrheic patient with a virilizing adrenal adenoma, under the following conditions: 1) control for 2 days, 2) dexamethasone, 0.5 mg, every 6 hours for 2 days, and 3) dexamethasone, 2 mg, every 6 hours for 2 days. Except for E1, E2, and F, the control levels of all steroids measured were elevated, markedly so for delta5-P, 17-delta5-P, DHEA, A, and DHEA-S. Dexamethasone treatment had no detectable effect on the steroid levels. Following removal of the adrenal adenoma, the levels of all steroids returned to normal. The patient became eumenorrheic, with marked improvement of her hirsutism and virilization.
在一名患有男性化肾上腺腺瘤的闭经患者切除右侧肾上腺“致密细胞”腺瘤之前、术后1.5个月和9个月时，在以下条件下测量了孕烯醇酮（δ5-P）、17-羟孕烯醇酮（17-δ5-P）、孕酮（P）、17-羟孕酮（17-P）、睾酮（T）、5α-双氢睾酮（DHT）、雄烯二酮（A）、脱氢表雄酮（DHEA）、其硫酸盐（DHEA-S）、雌酮（E1）、雌二醇-17β（E2）和皮质醇（F）的外周水平：1）2天对照；2）地塞米松，0.5毫克，每6小时一次，共2天；3）地塞米松，2毫克，每6小时一次，共2天。除E1、E2和F外，所测所有类固醇的对照水平均升高，δ5-P、17-δ5-P、DHEA、A和DHEA-S的升高尤为明显。地塞米松治疗对类固醇水平无明显影响。切除肾上腺腺瘤后，所有类固醇水平恢复正常。患者月经恢复正常，多毛症和男性化症状明显改善。
