Maroulis G B, Abraham G E
Obstet Gynecol. 1976 Aug;48(2):150-4.
Serum levels of cortisol (F), pregnenolone (delta5-P), 17-hydroxypregnenolone (17-delta5-P), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), progesterone (P), 17-hydroxyprogesterone (17-P), androstenedione (A), testosterone (T), dihydrotestosterone (DHT), androst-5-ene-3beta, 17beta-diol (delta5-diol), estrone (E1), and estradiol-17beta (E2) were measured in 10 postmenopausal and 5 premenopausal women before (control) and after 7 days of Dexamethasone (post-dex). Control and post-dex levels of delta5-P, P, DHT, T, and F were not different (P greater than 0.05) in premenopausal versus postmenopausal women, while the control levels of 17-P, DHEA, DHEA-S, A, delta5-diol, and E2 were lower in the postmenopausal women (P less than 0.05). Assuming post-dex levels equal ovarian contribution, the ovarian contribution of 17-delta5-P, 17-P, DHEA, delta5-diol, A, E1, and E2 and the adrenal contribution (control-post-dex) to DHEA, DHEA-S, 17-P, A, and delta5-diol was significantly lower (P less than 0.05) in postmenopausal subjects.
在10名绝经后女性和5名绝经前女性中，于地塞米松治疗前（对照）和治疗7天后（地塞米松治疗后）测定血清中皮质醇（F）、孕烯醇酮（δ5-P）、17-羟孕烯醇酮（17-δ5-P）、脱氢表雄酮（DHEA）、硫酸脱氢表雄酮（DHEA-S）、孕酮（P）、17-羟孕酮（17-P）、雄烯二酮（A）、睾酮（T）、双氢睾酮（DHT）、雄甾-5-烯-3β,17β-二醇（δ5-二醇）、雌酮（E1）和雌二醇-17β（E2）的水平。绝经前女性与绝经后女性相比，δ5-P、P、DHT、T和F的对照水平与地塞米松治疗后水平无差异（P>0.05），而绝经后女性中17-P、DHEA、DHEA-S、A、δ5-二醇和E2的对照水平较低（P<0.05）。假设地塞米松治疗后水平等同于卵巢的贡献，绝经后受试者中17-δ5-P、17-P、DHEA、δ5-二醇、A、E1和E2的卵巢贡献以及肾上腺对DHEA、DHEA-S、17-P、A和δ5-二醇的贡献（对照-地塞米松治疗后）显著较低（P<0.05）。
