印记微小RNA基因以反义方向转录，与一个相互印记的反转录转座子样基因相对。

Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene.

作者信息

Seitz Hervé, Youngson Neil, Lin Shau-Ping, Dalbert Simone, Paulsen Martina, Bachellerie Jean-Pierre, Ferguson-Smith Anne C, Cavaillé Jérôme

机构信息

LBME, Centre National de la Recherche Scientifique, UMR 5099, IFR 109, Université P. Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex, France.

出版信息

Nat Genet. 2003 Jul;34(3):261-2. doi: 10.1038/ng1171.

DOI:10.1038/ng1171

PMID:12796779

Abstract

MicroRNAs (miRNAs) are an abundant class of RNAs that are approximately 21-25 nucleotides (nt) long, interact with mRNAs and trigger either translation repression or RNA cleavage (RNA interference, RNAi) depending on the degree of complementarity with their targets. Here we show that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes expressed from the maternally inherited chromosome and antisense to a retrotransposon-like gene (Rtl1) expressed only from the paternal allele.

摘要

微小RNA（miRNA）是一类丰富的RNA，长度约为21 - 25个核苷酸（nt），与信使核糖核酸（mRNA）相互作用，并根据与靶标的互补程度触发翻译抑制或RNA切割（RNA干扰，RNAi）。我们在此表明，印记的小鼠12号远端染色体位点编码两个从母系遗传染色体表达的miRNA基因，且与仅从父本等位基因表达的反转录转座子样基因（Rtl1）呈反义关系。