长期慢性活动性EB病毒（CAEBV）感染后，通过异基因骨髓移植成功治疗自然杀伤（NK）细胞白血病。

Successful treatment of natural killer (NK) cell leukemia following a long-standing chronic active Epstein-Barr virus (CAEBV) infection with allogeneic bone marrow transplantation.

作者信息

Ebihara Y, Manabe A, Tanaka R, Yoshimasu T, Ishikawa K, Iseki T, Hayakawa J, Maeda M, Asano S, Tsuji K

机构信息

Department of Pediatric Hematology/Oncology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

出版信息

Bone Marrow Transplant. 2003 Jun;31(12):1169-71. doi: 10.1038/sj.bmt.1704078.

DOI:10.1038/sj.bmt.1704078

PMID:12796798

Abstract

The optimal treatment for natural killer (NK) cell leukemia after chronic active Epstein-Barr virus (CAEBV) infection has not been determined. A 15-year-old boy presented with NK cell leukemia following CAEBV infection for 5 years. The peripheral blood and BM had an increased number of CD3(-)CD56(+) large granular lymphocytes and a monoclonal integration of the EBV genome was detected. Chemotherapy was not sufficiently effective to control the disease. Allogeneic BMT from an HLA-identical sister was performed using a conditioning regimen consisting of total body irradiation, cyclophosphamide and thiotepa. The patient is disease-free with a perfect performance status 24 months after BMT. This is the first report to show that allogeneic BMT is potentially able to cure NK cell leukemia after CAEBV infection.

摘要

慢性活动性EB病毒（CAEBV）感染后自然杀伤（NK）细胞白血病的最佳治疗方案尚未确定。一名15岁男孩在CAEBV感染5年后出现NK细胞白血病。外周血和骨髓中CD3(-)CD56(+)大颗粒淋巴细胞数量增加，检测到EBV基因组的单克隆整合。化疗对控制疾病效果不佳。采用全身照射、环磷酰胺和噻替派组成的预处理方案，对一名 HLA 相同的姐姐进行了异基因骨髓移植。骨髓移植后24个月，患者疾病无复发，身体状况良好。这是第一份表明异基因骨髓移植可能治愈CAEBV感染后NK细胞白血病的报告。