Eckard Allison Ross, Leong Traci, Avery Ann, Castillo Marina Duran, Bonilla Hector, Storer Norma, Labbato Danielle, Khaitan Alka, Tangpricha Vin, McComsey Grace A
Emory University School of Medicine, Atlanta, Georgia 30322, USA.
AIDS Res Hum Retroviruses. 2013 Sep;29(9):1224-8. doi: 10.1089/aid.2012.0384. Epub 2013 Jun 15.
Vitamin D deficiency is common in HIV-infected populations. In resource-limited settings, vitamin D deficiency has been shown to affect HIV disease progression and mortality in pregnant women, and also increases mother-to-child HIV transmission and mortality in their infants. This study sought to investigate vitamin D status in HIV-infected women compared to healthy controls in a high-income country setting and determine variables associated with vitamin D deficiency. We prospectively enrolled 40 women/infant pairs (16 HIV-infected women/HIV-exposed infant pairs and 24 uninfected/unexposed pairs). In serum cord blood, 25-hydroxyvitamin D [25(OH)D] concentrations were suboptimal (<30 ng/ml) in 100% of subjects from both groups. White race, non-Hispanic ethnicity was the only variable associated with higher serum 25(OH)D concentrations. This high prevalence of vitamin D deficiency, especially among HIV-infected women and their infants, deserves further investigation, as it may have a negative impact on maternal and infant health.
维生素D缺乏在艾滋病毒感染人群中很常见。在资源有限的环境中，维生素D缺乏已被证明会影响孕妇的艾滋病毒疾病进展和死亡率，还会增加母婴间艾滋病毒传播以及婴儿的死亡率。本研究旨在调查在高收入国家环境中，与健康对照组相比，艾滋病毒感染女性的维生素D状况，并确定与维生素D缺乏相关的变量。我们前瞻性地招募了40对母婴（16对艾滋病毒感染女性/艾滋病毒暴露婴儿对和24对未感染/未暴露对）。在血清脐带血中，两组所有受试者的25-羟基维生素D [25(OH)D] 浓度均未达到最佳水平（<30 ng/ml）。白人种族、非西班牙裔是与较高血清25(OH)D浓度相关的唯一变量。维生素D缺乏的高患病率，尤其是在艾滋病毒感染女性及其婴儿中，值得进一步研究，因为这可能会对母婴健康产生负面影响。
