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肺包虫病

Pulmonary echinococcosis.

作者信息

Morar R, Feldman C

机构信息

Dept of Medicine, Division of Pulmonology, Johannesburg Hospital and University of the Witwatersrand, Johannesburg, South Africa.

出版信息

Eur Respir J. 2003 Jun;21(6):1069-77. doi: 10.1183/09031936.03.00108403.

Abstract

Echinococcosis or hydatid disease is caused by larvae of the tapeworm Echinococcus. Four species are recognised and the vast majority of infestations in humans are caused by E. granulosus. E. granulosus causes cystic echinococcosis, which has a worldwide distribution. Humans are exposed less frequently to E. multilocularis, which causes alveolar echinococcosis. E. vogeli and E. oligarthrus are rare species and cause polycystic echinococcosis. In cystic echinococcosis, humans are an accidental host and are usually infected by handling an infected dog. The liver and lungs are the most frequently involved organs. Pulmonary disease appears to be more common in younger individuals. Although most patients are asymptomatic, some may occasionally expectorate the contents of the cyst or develop symptoms related to compression of the surrounding structures. Other symptoms of hydatid disease can result from the release of antigenic material and secondary immunological reactions that develop from cyst rupture. The cysts are characteristically seen as solitary or multiple circumscribed or oval masses on imaging. Detection of antibody directed against specific echinococcal antigens is found in only approximately half of patients with pulmonary cysts. Surgical excision of the cyst is the treatment of choice whenever feasible.

摘要

棘球蚴病或包虫病是由棘球绦虫的幼虫引起的。已确认有四种,绝大多数人类感染是由细粒棘球绦虫引起的。细粒棘球绦虫引起囊性棘球蚴病,该病分布于世界各地。人类较少接触多房棘球绦虫,它会引起泡型棘球蚴病。伏氏棘球绦虫和少节棘球绦虫是罕见种类,会引起多囊性棘球蚴病。在囊性棘球蚴病中,人类是偶然宿主,通常因接触受感染的狗而被感染。肝脏和肺是最常受累的器官。肺部疾病在较年轻个体中似乎更常见。虽然大多数患者无症状,但有些人可能偶尔咳出囊肿内容物或出现与周围结构受压相关的症状。包虫病的其他症状可能源于抗原物质的释放以及囊肿破裂引发的继发性免疫反应。在影像学上,囊肿典型地表现为单个或多个边界清晰的圆形或椭圆形肿块。仅约一半的肺囊肿患者能检测到针对特定棘球蚴抗原的抗体。只要可行,手术切除囊肿是首选治疗方法。

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