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双侧肺包虫囊肿的治疗方法:107例连续病例分析

Treatment approach in bilateral pulmonary hydatid cysts: analysis of 107 consecutive cases.

作者信息

Aydin Yener, Ulas Ali Bilal, Kasali Kamber, Dostbil Aysenur, Ince Ilker, Eroglu Atilla, Kocak Hikmet

机构信息

Medical Faculty, Department of Thoracic Surgery, Ataturk University, 25240 Erzurum, Turkey.

Medical Faculty, Department of Biostatistics, Ataturk University, Erzurum, Turkey.

出版信息

Indian J Thorac Cardiovasc Surg. 2024 Nov;40(6):669-674. doi: 10.1007/s12055-024-01750-5. Epub 2024 May 20.

Abstract

OBJECTIVE

Bilateral pulmonary involvement is observed in around 14% of cases of pulmonary hydatid cysts and the treatment can be challenging. This study evaluates the clinical characteristics and treatment strategies used for cases of bilateral pulmonary hydatid cysts.

MATERIALS AND METHODS

A retrospective examination was conducted on 107 consecutive cases of bilateral pulmonary hydatid cysts treated in our clinic between January 2003 and December 2023.

RESULTS

Out of the 107 cases analyzed, 57 (53.3%) were male and 50 (46.7%) were female. Surgical intervention was performed for pulmonary hydatid cysts in 92 cases (86.0%), while medical treatment was prescribed for the remaining 15 cases (14.0%). Bilateral thoracotomies were consecutively conducted in 77 cases; in 11 cases, thoracotomy was carried out on one side and contralateral hydatid cysts were treated medically. Three cases underwent sternotomy, and one underwent bilateral thoracotomy during a single session. One case experienced postoperative hemorrhage, three cases had prolonged air leakage, two cases had empyema, one case had a wound infection, and one case had a recurrence of hydatid cyst. For bilaterally operated cases, albendazole treatment commenced after the second operation and was carried out in two 15-day cycles. Patients who declined, or were not eligible for surgery, were treated with albendazole for an extended period.

CONCLUSIONS

Consecutive bilateral thoracotomy, followed by two cycles of albendazole therapy, is a highly effective treatment for patients with bilateral pulmonary hydatid cysts. In cases with widespread involvement, ruptured small cysts, or serious comorbidities, long-term medical treatment including albendazole administration may be applied.

摘要

目的

在约14%的肺包虫囊肿病例中观察到双侧肺部受累,其治疗可能具有挑战性。本研究评估双侧肺包虫囊肿病例的临床特征及治疗策略。

材料与方法

对2003年1月至2023年12月在我院连续治疗的107例双侧肺包虫囊肿病例进行回顾性检查。

结果

在分析的107例病例中,男性57例(53.3%),女性50例(46.7%)。92例(86.0%)肺包虫囊肿患者接受了手术干预,其余15例(14.0%)接受了药物治疗。77例患者连续进行了双侧开胸手术;11例患者一侧进行了开胸手术,对侧的包虫囊肿进行了药物治疗。3例患者接受了胸骨切开术,1例患者在一次手术中进行了双侧开胸手术。1例患者术后出血,3例患者出现持续漏气,2例患者发生脓胸,1例患者伤口感染,1例患者包虫囊肿复发。对于双侧手术的病例,阿苯达唑治疗在第二次手术后开始,分两个15天周期进行。拒绝手术或不适合手术的患者接受了更长时间的阿苯达唑治疗。

结论

连续双侧开胸手术,随后进行两个周期的阿苯达唑治疗,是治疗双侧肺包虫囊肿患者的一种高效治疗方法。在广泛受累、小囊肿破裂或合并严重疾病的情况下,可采用包括阿苯达唑给药在内的长期药物治疗。

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本文引用的文献

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Pulmonary cystic echinococcosis.肺包虫病。
Curr Opin Infect Dis. 2023 Oct 1;36(5):318-325. doi: 10.1097/QCO.0000000000000962. Epub 2023 Aug 14.
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Pulmonary Hydatid Cyst in Children and Adults: Diagnosis and Management.儿童及成人肺包虫囊肿:诊断与治疗
Eurasian J Med. 2022 Dec;54(Suppl1):133-140. doi: 10.5152/eurasianjmed.2022.22289.
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Paediatric pulmonary echinococcosis: A neglected disease.小儿肺包虫病:一种被忽视的疾病。
Paediatr Respir Rev. 2022 Sep;43:11-23. doi: 10.1016/j.prrv.2021.11.001. Epub 2021 Dec 3.
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Monaldi Arch Chest Dis. 2021 Sep 14;92(1). doi: 10.4081/monaldi.2021.1770.
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Pulmonary Echinococcosis or Lung Hydatidosis: A Narrative Review.肺包虫病或肺包虫囊肿病:一种叙述性综述。
Surg Infect (Larchmt). 2021 Jun;22(5):485-495. doi: 10.1089/sur.2020.197. Epub 2020 Dec 9.
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Int J Surg Case Rep. 2020;76:130-133. doi: 10.1016/j.ijscr.2020.09.070. Epub 2020 Sep 16.
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Pulmonary hydatid cyst: Review of literature.肺包虫囊肿:文献综述
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