Paes Leme Adriana Franco, Tabchoury Cinthia Pereira Machado, Zero Domenick Thomas, Cury Jaime Aparecido
Department of Physiological Sciences, Faculty of Dentistry of Piracicaba, State University of Campinas, SP, Brazil.
Am J Dent. 2003 Apr;16(2):91-5.
To evaluate the effect of a combination of fluoride dentifrice and acidulated phosphate fluoride (APF) on enamel with incipient caries lesions.
Bovine dental enamel blocks with artificial caries lesions were divided into four treatment groups and submitted to a pH-cycling model: (1) Placebo non-fluoridated dentifrice (PD); (2) Fluoridated dentifrice (FD), 1,100 ppm F; (3) APF (12,300 ppm F, pH 3.5) + PD; 4) APF+FD. APF was applied to enamel blocks of groups APF+PD and APF+FD before the pH-cycling regimen and all of them were exposed to dentifrice during the cycling.
The results showed that 61-81% of the fluoride previously deposited in enamel by APF was released to the media during the pH-cycling. The final concentration of fluoride in enamel in the group APF+PD was lower than that before the cycling (P < 0.05), but in the group APF+FD the reduction was not significant (P> 0.05). FD treatment was significantly more efficient than PD in rehardening the enamel surface and increasing the hardness of the caries lesions. APF+PD treatment was not more efficient than PD in increasing enamel hardness and an additive effect of APF+FD was not observed.
评估含氟牙膏与酸化磷酸氟（APF）联合使用对早期龋损牙釉质的影响。
将有人工龋损的牛牙釉质块分为四个治疗组，并采用pH循环模型：（1）安慰剂非氟化牙膏（PD）；（2）含氟牙膏（FD），氟含量1100 ppm；（3）APF（氟含量12300 ppm，pH 3.5）+PD；（4）APF+FD。在pH循环方案之前，将APF应用于APF+PD组和APF+FD组的牙釉质块，并且在循环过程中所有组都接触牙膏。
结果显示，在pH循环过程中，先前由APF沉积在牙釉质中的氟有61%-81%释放到培养基中。APF+PD组牙釉质中氟的最终浓度低于循环前（P<0.05），但APF+FD组的降低不显著（P>0.05）。在使牙釉质表面再矿化和增加龋损硬度方面，FD治疗比PD显著更有效。APF+PD治疗在增加牙釉质硬度方面不比PD更有效，并且未观察到APF+FD的相加作用。
