Rabec C, Barcat J, Rey D
División de Neumología (Dra. M.C. de Salvo). Centro de Insuficiencia Respiratoria y Patología Respiratoria del Sueño. Hospital Tornu. Buenos Aires. Argentina.
Arch Bronconeumol. 2003 Jun;39(6):283-5. doi: 10.1016/s0300-2896(03)75381-2.
Diffuse alveolar hemorrhage (DAH) is characterized by diffuse bleeding into alveolar spaces. Three histopathological patterns may be seen: 1) pulmonary capillaritis due to immunological aggression to the membrane, 2) diffuse alveolar damage within the context of acute respiratory distress syndrome, and 3) and "bland" DAH without alveolar or capillary damage. In the first two groups, pulmonary damage usually occurs within the context of a systemic disease. In the last, injury is usually found only in the lung, an entity called pulmonary hemosiderosis. We present a case of DAH with neither capillaritis nor diffuse alveolar damage in association with inflammatory bowel disease and Hashimoto thyroiditis. The case is interesting both because the association has not yet been described in the literature and because the presence of alveolar bleeding without evident tissue damage within the context of known autoimmune diseases may extend the field to include a new pathophysiological mechanism of pulmonary hemorrhage.
弥漫性肺泡出血(DAH)的特征是血液弥漫性渗入肺泡腔。可观察到三种组织病理学模式:1)因免疫攻击肺泡膜导致的肺毛细血管炎;2)急性呼吸窘迫综合征背景下的弥漫性肺泡损伤;3)无肺泡或毛细血管损伤的“单纯性”DAH。在前两组中,肺损伤通常发生在全身性疾病的背景下。在最后一组中,损伤通常仅见于肺部,即所谓的肺含铁血黄素沉着症。我们报告一例既无毛细血管炎也无弥漫性肺泡损伤的DAH病例,该病例与炎症性肠病和桥本甲状腺炎相关。该病例很有意思,一方面是因为这种关联尚未见文献报道,另一方面是因为在已知自身免疫性疾病背景下存在无明显组织损伤的肺泡出血,这可能拓展了领域,纳入一种新的肺出血病理生理机制。