技能学习与可塑性的胆碱能调节
Cholinergic modulation of skill learning and plasticity.
作者信息
Kilgard Michael
机构信息
Department of Cognition and Neuroscience, University of Texas, Dallas, School of Human Development, Gr 41, Richardson, TX 75083, USA.
出版信息
Neuron. 2003 Jun 5;38(5):678-80. doi: 10.1016/s0896-6273(03)00327-1.
Abstract
The basal forebrain cholinergic system strongly influences both cortical plasticity and learning. Directly relating these two roles has proven difficult. New results indicate that nucleus basalis lesions prevent motor cortex map plasticity and impair skill learning. These results strengthen the hypothesis that nucleus basalis gates neural plasticity necessary for instrumental learning.
摘要
基底前脑胆碱能系统对皮质可塑性和学习均有强烈影响。事实证明，直接将这两种作用联系起来颇具难度。新的研究结果表明，基底核损伤会妨碍运动皮质图谱的可塑性，并损害技能学习。这些结果强化了如下假说，即基底核为工具性学习所需的神经可塑性提供了门户。
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