Yasuma T, Arai K, Suzuki F
Department of Orthopaedic Surgery, Kouto Hospital, Tokyo, Japan.
Spine (Phila Pa 1976). 1992 Oct;17(10):1194-8. doi: 10.1097/00007632-199210000-00011.
In 69 lumbar intervertebral discs from 69 autopsies, lipofuscin was seen in discs from individuals older than 50 years of age and amyloids in the discs of individuals older than 40 years of age. In 261 intervertebral disc tissue specimens collected at the time of surgery for disc herniation, lipofuscin was seen in the discs of individuals older than 20 years of age and amyloids in the discs of individuals older than 15 years of age. It is speculated that amyloids and lipofuscin are a sign of aging in the intervertebral disc as in other tissues. Furthermore, amyloids and lipofuscin were seen in the operated discs of young individuals than in the autopsy cases.
在69例尸检的69个腰椎椎间盘中，在50岁以上个体的椎间盘中可见脂褐素，在40岁以上个体的椎间盘中可见淀粉样蛋白。在因椎间盘突出症手术时采集的261个椎间盘组织标本中，在20岁以上个体的椎间盘中可见脂褐素，在15岁以上个体的椎间盘中可见淀粉样蛋白。据推测，与其他组织一样，淀粉样蛋白和脂褐素是椎间盘老化的标志。此外，在年轻个体的手术椎间盘中比在尸检病例中更易见到淀粉样蛋白和脂褐素。
