Semenkova G G, Sil'vestrov V P, Provotorov V M
Ter Arkh. 1992;64(3):66-71.
An analysis was made of the short- and long-term (1.5-2 years) results of the treatment of 75 patients with acute abscess and 101 with lingering pneumonia using different routes of administration of proteinase inhibitors and antibiotics. The high efficacy was demonstrated of the local intrapulmonary and endobronchial administration of the proteinase inhibitor contrykal and antibiotics. The treatment method suggested was found to compare favourably with the common route of the drug administration. The treatment is well tolerated and promotes the shortening of the times of the patients' stay in the hospital, reduces the number of complications and residual phenomena, prevents the disease relapses and their transformation to chronic nonspecific pulmonary diseases. The clinical recovery of the patients with acute lung abscess was reached in 91.4% of cases whereas in the reference group, only in 66.7%. In the patients with lingering pneumonia, the recovery was noted in 85.4%, in the reference group, in 27.5% of cases.
对75例急性脓肿患者和101例迁延性肺炎患者采用蛋白酶抑制剂和抗生素的不同给药途径进行治疗的短期和长期(1.5 - 2年)结果进行了分析。结果表明,蛋白酶抑制剂康胰酶(Contrykal)与抗生素经肺内局部和支气管内给药具有高效性。所建议的治疗方法被发现优于药物的常规给药途径。该治疗耐受性良好,可缩短患者住院时间,减少并发症和残留现象的数量,预防疾病复发及其转变为慢性非特异性肺部疾病。急性肺脓肿患者的临床治愈率在91.4%的病例中达到,而在参照组中仅为66.7%。在迁延性肺炎患者中,治愈率为85.4%,在参照组中为27.5%。