[Clinical efficacy and pathogenetic validation of the intrapulmonary and intrabronchial administration of proteinase inhibitors and antibiotics in the treatment of patients with nonspecific lung diseases].

Eighty patients (34 with lung abscess, 39 with lingering pneumonia associated with chronic bronchitis) were examined for the activity of the proteinase inhibitory system in bronchial washing off as well as for the level of alpha 1-proteinase inhibitor in blood serum. The system of proteinases inhibitors was found to be unbalanced with the predominance of proteinases. The proteinase inhibitor contrycal was included into the multimodality treatment of patients. The patients of the main group were administered contrycal and antibiotics intrapulmonarily with the aid of a needle jet injector (NJI-1) and endobronchially, whereas the control group patients were given intravenous injections in the identical daily and total dose. The local (intrapulmonary and endobronchial) administration of proteinase inhibitors and antibiotics turned out to compare very favourably with intravenous injection of the same remedies.