McDougal Patrick G, Griffin John H
Department of Chemistry, Stanford University, 94305-5080, Stanford, CA, USA.
Bioorg Med Chem Lett. 2003 Jul 7;13(13):2239-40. doi: 10.1016/s0960-894x(03)00252-x.
The enantiomer of the antibiotic bacitracin A was prepared by solid-phase total synthesis. ent-Bacitracin A was found to be equally potent to the natural enantiomer in in vitro susceptibility assays. This supports the notion that bacitracin exerts its antibacterial effects through interaction with bactoprenylpyrophosphate, an achiral ligand.
抗生素杆菌肽A的对映体通过固相全合成制备。在体外药敏试验中发现对映体杆菌肽A与天然对映体具有同等效力。这支持了杆菌肽通过与无手性配体细菌萜醇焦磷酸相互作用发挥抗菌作用的观点。
