葡萄球菌素多种类似物的合成及其抗菌活性。
Synthesis of diverse analogues of Oenostacin and their antibacterial activities.
作者信息
Srivastava Vandana, Darokar Mahendra P, Fatima Atiya, Kumar J K, Chowdhury Chinmay, Saxena Hari Om, Dwivedi Gaurav R, Shrivastava Kunal, Gupta Vivek, Chattopadhyay S K, Luqman Suaib, Gupta M M, Negi Arvind S, Khanuja Suman P S
机构信息
Central Institute of Medicinal and Aromatic Plants (CIMAP), PO CIMAP, Kukrail Picnic Spot Road, Lucknow 226 015, India.
出版信息
Bioorg Med Chem. 2007 Jan 1;15(1):518-25. doi: 10.1016/j.bmc.2006.09.034. Epub 2006 Oct 10.
Several diverse analogues of Oenostacin, a naturally occurring potent antibacterial phenolic acid derivative, have been synthesized. A small library with more than forty analogues having different aromatic rings and varied side chains has been achieved through solution phase synthesis. Some of these analogues, that is, 22, 23 and 42, possessed potent antibacterial activities against Staphylococcus epidermidis and Staphylococcus aureus having EC(50) ranging from 0.49 to 0.67 microM as compared to Oenostacin (EC(50)=0.12 microM).
已合成了几种天然存在的强效抗菌酚酸衍生物oenostacin的不同类似物。通过溶液相合成获得了一个包含四十多种具有不同芳环和不同侧链的类似物的小型文库。其中一些类似物，即22、23和42，对表皮葡萄球菌和金黄色葡萄球菌具有强效抗菌活性，其半数有效浓度（EC(50)）范围为0.49至0.67微摩尔，而oenostacin的EC(50)为0.12微摩尔。
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