Esposito Susanna, Madore Dace V, Gironi Stefania, Bosis Samantha, Tosi Silvia, Bianchi Ciro, Cimino Carolyn, Principi Nicola
Pediatric Department I, via Commenda 9, 20122 Milan, Italy.
Vaccine. 2003 Jun 20;21(21-22):2704-7. doi: 10.1016/s0264-410x(03)00110-5.
In order to evaluate the theoretic coverage of the heptavalent conjugate vaccine against community-acquired pneumonia (CAP) during the first years of life, the anti-capsular IgG antibodies to the nine more common pneumococcal serotypes (1, 4, 5, 6B, 9V, 14, 18C, 19F, 23F) were quantitated in 196 affected children aged 2-5 years by means of enzyme-linked immunosorbent assays of acute and convalescent serum samples. Acute Streptococcus pneumoniae infection associated with the nine tested serotypes was diagnosed in 57 children (29.1%). Serological data indicated that 16.8% of CAPs were caused by serotypes included in the heptavalent conjugate vaccine. This study confirms the significant role of S. pneumoniae in pediatric CAP, and highlights the importance of pneumococcal conjugate vaccines in preventing it during the first years of life.
为了评估七价结合疫苗在生命最初几年对社区获得性肺炎（CAP）的理论覆盖率，通过对196名2至5岁受影响儿童的急性和恢复期血清样本进行酶联免疫吸附测定，对九种更常见的肺炎球菌血清型（1、4、5、6B、9V、14、18C、19F、23F）的抗荚膜IgG抗体进行了定量。57名儿童（29.1%）被诊断为与九种测试血清型相关的急性肺炎链球菌感染。血清学数据表明，16.8%的CAP由七价结合疫苗包含的血清型引起。本研究证实了肺炎链球菌在儿童CAP中的重要作用，并强调了肺炎球菌结合疫苗在生命最初几年预防该病的重要性。
