[引起急性细菌性脑膜炎的非疫苗型肺炎链球菌血清型]

[Nonvaccine Streptococcus pneumoniae serotypes causing acute bacterial meningitis].

作者信息

Luque Moreno A, Bergadà Masó A, Sin Opi J M, Liarte Guillén A, Mayol L, Macià Martí J

机构信息

Servicio de Pediatría, Hospital Universitario de Girona Doctor Josep Trueta, Girona, Spain.

出版信息

An Pediatr (Barc). 2006 Feb;64(2):170-2. doi: 10.1157/13084179.

DOI:10.1157/13084179

PMID:16527072

Abstract

The pneumococcal heptavalent conjugate vaccine protects children aged less than 2 years old from invasive pneumococcal disease (IPD). Efficacy is 89-93% in the US population and 71-86% in European studies. The vaccine confers active immunization against the main serotypes causing IPD (4, 6B, 9V, 14, 18C, 19F y 23F). We describe 2 children who presented with pneumococcal meningitis caused by nonvaccine serotypes. As a result of the widespread use of the heptavalent vaccine, there may be a shift in the serotypes causing IPD.

摘要

肺炎球菌七价结合疫苗可保护2岁以下儿童免受侵袭性肺炎球菌疾病（IPD）的侵害。在美国人群中，其有效性为89%-93%，在欧洲的研究中为71%-86%。该疫苗可对引起IPD的主要血清型（4、6B、9V、14、18C、19F和23F）进行主动免疫。我们描述了2例由非疫苗血清型引起的肺炎球菌脑膜炎患儿。由于七价疫苗的广泛使用，引起IPD的血清型可能会发生变化。