Revest P A, Abbott N J
Biomedical Sciences Division, King's College, London, UK.
Trends Pharmacol Sci. 1992 Nov;13(11):404-7. doi: 10.1016/0165-6147(92)90124-o.
It is becoming clear that endothelial cells in the vascular system have important functions. In the microvessels they play an active role in regulating vascular permeability, while in large vessels, endothelial cells contribute to the control of smooth muscle tone. Control of both permeability and tone involve a range of mechanisms, in which changes in [Ca2+]i appear to play a major role. As elevation of [Ca2+]i can be caused by either release from intracellular stores or increased entry across the plasmalemma, and as the latter will be modulated by the resting membrane potential, the ion channels controlling the membrane potential are critical to an understanding of endothelial function. Patricia Revest and Joan Abbott summarize the properties of endothelial ion channels, and explore the ways in which the channels could control permeability, secretion and smooth muscle tone.
越来越明显的是，血管系统中的内皮细胞具有重要功能。在微血管中，它们在调节血管通透性方面发挥积极作用，而在大血管中，内皮细胞有助于控制平滑肌张力。对通透性和张力的控制涉及一系列机制，其中细胞内钙离子浓度（[Ca2+]i）的变化似乎起着主要作用。由于[Ca2+]i的升高可能是由细胞内储存库释放或通过质膜的进入增加引起的，并且由于后者将受到静息膜电位的调节，控制膜电位的离子通道对于理解内皮功能至关重要。帕特里夏·雷维斯特和琼·阿博特总结了内皮离子通道的特性，并探讨了这些通道控制通透性、分泌和平滑肌张力的方式。
