Gordienko D V, Tsukahara H
Department of Medicine, State University of New York at Stony Brook 11794-8152.
Pflugers Arch. 1994 Aug;428(1):91-3. doi: 10.1007/BF00374756.
Voltage-dependent Na+ current (INa) was identified in cultured endothelial cells derived from rat interlobar artery (RIAE cells) and human umbilical vein (HUVE cells). Tetrodotoxin (TTX) reduced INa in a dose-dependent manner with the apparent dissociation constant (Kd) of 1.4 microM. Low sensitivity of INa to TTX as well as its kinetics and voltage-dependent properties indicates that voltage-gated Na channels expressed in vascular endothelial cells belong to the so-called TTX-resistant type.
在源自大鼠叶间动脉的培养内皮细胞（RIAE细胞）和人脐静脉（HUVE细胞）中鉴定出电压依赖性钠电流（INa）。河豚毒素（TTX）以剂量依赖性方式降低INa，其表观解离常数（Kd）为1.4微摩尔。INa对TTX的低敏感性及其动力学和电压依赖性特性表明，血管内皮细胞中表达的电压门控钠通道属于所谓的耐河豚毒素型。
