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综述：戈利蛋白在免疫系统中的表达与功能

Minireview: expression and function of golli protein in immune system.

作者信息

Feng Ji-Ming

机构信息

Semel Institute of Neuroscience, UCLA Geffen School of Medicine, Neuroscience Research Building Room 304, 635 Charles Young Drive, Los Angeles, CA 90095-7332, USA.

出版信息

Neurochem Res. 2007 Feb;32(2):273-8. doi: 10.1007/s11064-006-9164-1. Epub 2006 Oct 6.

DOI:10.1007/s11064-006-9164-1
PMID:17024569
Abstract

In this minireview, the author briefly reviews the development of our understanding on the immunological function of golli proteins. In the immune system, in addition to serving as autoantigens, golli proteins have been recently found to regulate T-cell activation directly, thus modulating EAE induction. The evidence that golli proteins function as signal molecules is summarized.

摘要

在本综述中，作者简要回顾了我们对golli蛋白免疫功能认识的发展历程。在免疫系统中，除了作为自身抗原外，近来还发现golli蛋白可直接调节T细胞活化，进而调控实验性自身免疫性脑脊髓炎（EAE）的诱导。本文总结了golli蛋白作为信号分子发挥作用的证据。

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Minireview: expression and function of golli protein in immune system.综述：戈利蛋白在免疫系统中的表达与功能
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2
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Immunity. 2006 Jun;24(6):717-727. doi: 10.1016/j.immuni.2006.04.007.
2
Structural disorder throws new light on moonlighting.结构紊乱为兼职现象带来了新的启示。
Trends Biochem Sci. 2005 Sep;30(9):484-9. doi: 10.1016/j.tibs.2005.07.008.
3
Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis.在两种多发性硬化症小鼠模型中，表位扩展在中枢神经系统中启动。
多组学揭示高产蛋鸡品系免疫和代谢系统中的不同策略。
Front Genet. 2022 Apr 1;13:858232. doi: 10.3389/fgene.2022.858232. eCollection 2022.
4
Transcriptional regulators of the Golli/myelin basic protein locus integrate additive and stealth activities.Golli/髓鞘碱性蛋白基因座的转录调控因子整合了累加和隐匿活性。
PLoS Genet. 2020 Aug 13;16(8):e1008752. doi: 10.1371/journal.pgen.1008752. eCollection 2020 Aug.
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Interaction of the cryptic fragment of myelin basic protein with mitochondrial voltage-dependent anion-selective channel-1 affects cell energy metabolism.髓鞘碱性蛋白的隐蔽片段与线粒体电压依赖性阴离子选择性通道-1 的相互作用影响细胞能量代谢。
Biochem J. 2018 Jul 31;475(14):2355-2376. doi: 10.1042/BCJ20180137.
6
Changes of gene expression in T lymphocytes following Golli‑MBP gene RNA interference.Golli-MBP基因RNA干扰后T淋巴细胞中基因表达的变化
Mol Med Rep. 2016 Nov;14(5):4575-4580. doi: 10.3892/mmr.2016.5850. Epub 2016 Oct 13.
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Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8856-61. doi: 10.1073/pnas.122079599.