小儿麻痹后遗症和既往麻痹性脊髓灰质炎中的GM1抗体。

GM1 antibodies in post-polio syndrome and previous paralytic polio.

作者信息

Farbu E, Rekand T, Tysnes O-B, Aarli J A, Gilhus N E, Vedeler C A

机构信息

Department of Neurology, Haukeland University Hospital, University of Bergen, N-5021, Bergen, Norway.

出版信息

J Neuroimmunol. 2003 Jun;139(1-2):141-4. doi: 10.1016/s0165-5728(03)00123-1.

DOI:10.1016/s0165-5728(03)00123-1

PMID:12799031

Abstract

We studied the relationship between post-polio syndrome (PPS) and GM1 antibodies, since such antibodies have been associated with PPS and motor neuron disorders. Sera from 144 patients with previous poliomyelitis (105 paralytic, 22 nonparalytic and 17 PPS), 60 with previous Guillain-Barré syndrome, 44 with amyotrophic lateral sclerosis (ALS) and 22 healthy blood donors were analyzed with ELISA for GM1 IgM, IgG and IgA antibodies. GM1 antibodies were present in 14% of the PPS patients, but the prevalence did not differ significantly from that of the other groups. Our study does not support the hypothesis that GM1 antibodies are involved in the pathogenesis of PPS.

摘要

我们研究了小儿麻痹后遗症（PPS）与GM1抗体之间的关系，因为此类抗体已被证实与PPS及运动神经元疾病相关。我们采用酶联免疫吸附测定法（ELISA）对144例既往患过脊髓灰质炎的患者（105例麻痹型、22例非麻痹型和17例PPS患者）、60例既往患过格林-巴利综合征的患者、44例肌萎缩侧索硬化症（ALS）患者以及22名健康献血者的血清进行了GM1 IgM、IgG和IgA抗体分析。14%的PPS患者体内存在GM1抗体，但其患病率与其他组相比无显著差异。我们的研究不支持GM1抗体参与PPS发病机制的假说。